AFM-Plus Ophthalmic Ointment

Fluorometholone + Gentamicin

0.1%+0.3%

Aristopharma Ltd.

3 gm tube: ৳ 130.00

Indications

Inflammation associated with infections in the anterior segment of the eye due to bacteria susceptible to Gentamicin it is also indicated in postoperative infection.

Therapeutic Class

Ophthalmic steroid – antibiotic combined preparations

Pharmacology

Gentamicin belongs to the group of aminoglycoside antibiotics. It covers a broad spectrum of gram-positive and gram-negative pathogens, including Pseudomonas aeruginosa, Staphylococci, Haemophilus influenzae H. aegypticus, Klebsiella, Enterobacteria, Proteus, Escherichia coli, Shigella and Salmonella. It inhibits specifically bacterial protein synthesis. Fluorometholone is a synthetic fluorinated corticosteroid possessing anti-inflammatory properties. The combination brings concomitantly the bacterial treatment or prophylaxis and the anti-inflammatory effect. In addition, the presence of gentamicin protects from a risk of potential aggravation of a bacterial infection due to the steroid.

Dosage & Administration

Sterile Ophthalmic Suspension:

• Bacterial infection: The dosage depends on the severity of the disease. The application of 1 drop 5 times daily into the conjunctival sac of the affected eye is recommended. In severe cases the dosage can be increased up to 1 drop per hour for 1 to 2 days.
• Ocular postoperative infection: 1 drop 4 times daily into the conjunctival sac for 1 week. Then a reduced application frequency is recommended for the remaining part of the treatment.

Sterile Eye Ointment:

• Bacterial infection: Apply 3-4 times daily into the affected eye.
• Ocular postoperative infection: To support the therapy with Ophthalmic Suspension during the night apply ointment before retiring.

* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন‘

Contraindications

• Hypersensitivity to any of the components. Injuries and ulceration of the cornea. Viral infections (e.g. Herpes simplex, Vaccinia) or mycosis.
• Eye tuberculosis.
• Glaucoma.

Side Effects

A transient burning sensation may occur after instillation. Rare: Hypersensitivity reactions including eczema of the eyelid and puncture keratitis. Prolonged use of topical steroids may delay wound healing, increase of IOP, develop cataract and cause thinning of cornea & sclera.

Pregnancy & Lactation

No controlled studies in humans are available. Administration during pregnancy and lactation is therefore not recommended, except for compelling reasons.

Precautions & Warnings

• Steroids can mask, activate or aggravate ocular infections.
• Long-term treatment with steroid may enhance thinning of cornea and sclera and rarely perforation of the cornea has been reported.
• In case no improvement is observed after 7-8 days of treatment, other therapeutical means should be considered.
• Patients experiencing blurred vision after application of the product, particularly the ointment, should refrain from driving vehicles or operating machinery.
• Contact lenses should be removed before each application.

Storage Conditions

Store in a cool and dry place, protect from light. Do not use longer than 30 days after first opening. Keep out of reach of children.